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FLASH GENE
Symbol BOLL contributors: mct/npt - updated : 17-02-2010
HGNC name boll, boule-like (Drosophila)
HGNC id 14273
DNA
TYPE functioning gene
STRUCTURE 59.34 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text three alternatively spliced exons 1
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2779 - 295 only in germ cells Kee (2009)
11 splicing 2842 31 283 only in germ cells Kee (2009)
  • alternate 5' exon, downstream in frame start codon
  • shorter N terminus
  • major physiological role in complete spermatogenesis and meiotic arrest
  • - - 1270 - 289 only in germ cells Kostova (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single RNA binding domain with signature RNP1 and RNP2 repeats
  • a DAZ-like domain
  • HOMOLOGY
    interspecies homolog to Drosophila Boule
    homolog to murine Boule
    Homologene
    FAMILY
  • RRM DAZ family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text in the cytoplasm of primary spermatocytes
    basic FUNCTION
  • meiotic regulator,required for germ cell development and encoding an RNA-binding protein
  • a key conserved switch that regulates progression of germ cells through meiosis
  • PABP-binding protein that regulate translation in germ cells (Collier 2005)
  • playing an essential role for meiotic transition and thus for haploid germ cells production
  • promote later stages of meiosis and development of haploid gametes (Kee 2009)
  • functioning primarily to promote germ-cell progression to meiosis and formation of haploid germ cells that resemble round spermatids in cellular and molecular characteristics (Kee 2009)
  • stimulates CDC25A translation, and this effect does not involve alteration of mRNA stability (a decreased CDC25A expression caused by lack or decrease of BOLL may be associated with male infertility) (Lin 2009)
  • role in spermiogenesis, the differentiation of round spermatids into mature spermatozoa (Van Gompel 2010)
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS