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FLASH GENE
Symbol BDP1 contributors: mct/npt - updated : 04-04-2023
HGNC name B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
HGNC id 13652
Corresponding disease
DFNB112 neurosensory deafness 112
Location 5q13.2      Physical location : 70.751.441 - 70.863.649
Synonym name
  • transcription factor-like nuclear regulator
  • putative transcription factor-like nuclear regulator
  • TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1
  • transcription factor IIIB 150
  • Synonym symbol(s) DKFZp686K0831, DKFZp686C01233, TFC5, TFNR, TAF3B1, KIAA1241, KIAA1689, TFIIIB90, TFIIIB150, TFIIIB, HSA238520
    DNA
    TYPE functioning gene
    STRUCTURE 112.21 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S823 - CCNB1 - RAD17 - OCLN - [GTF2H2 - NAIP - SMN2 - SERF1B ] - (SERF1A - SMN1 - NAIP - GTF2H2 ) - BDP1 - D5S557 - D5S1408 - qter
    Authors Kelter (00)
    Text [centromeric unit], (telomeric unit)
    RNA
    TRANSCRIPTS type messenger
    text short copies maybe spliced, truncated copies or paralogues
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7193 252.8 2254 cerebellum 2017 28743884
    - splicing 4272 155.7 1388 weakly 2017 28743884
  • also called B''
  • lacking exon 15, truncated
  • - splicing 4273 155.6 1372 weakly 2017 28743884
  • also called B" short
  • remplacement of the 21 last Aas
  • - splicing - 89 796 weakly 2017 28743884
    lacking exon 15 truncated
    - - 4300 1388 - - 2017 28743884
    - splicing 4300 1372 - - 2017 28743884
    replacement of the last 21 amino acids with 5 different amino acids
    39 - 11097 293 2624 - 2017 28743884
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systembreastmammary gland moderately
     female systemuterus  moderately
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular Hydrophilic
    STRUCTURE
    motifs/domains
  • nine repeats of a 55 aa motif rich in serine, lysine, glutamic acid (coded by exon 17)
  • a bipartite nuclear localization signal (NLS)
  • a DNA ligase A1 ATP-dependent binding site
  • essential region of BDP1 that is positioned within the active site cleft of Pol III and necessary for transcription initiation
  • a second NLS in the C terminal region
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae TFC7
    homolog to murine Bdp1 (53 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • acting as a transcription factor-like nuclear regulator
  • required for transcription from the Ad2 VAI and human U6RNA polymerase III promotors
  • transcription factor BDP1 is crucial to Pol III recruitment and promoter opening in transcription initiation
  • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the U6 initiation complex
  • subunit of the TFIIIB transcription initiation complex
  • three components (TBP, BRF1, and BDP1) in TFIIIB participate in crucial molecular events that include RNA polymerase recruitment, formation of the open initiation complex, and recycling of transcription
  • INTERACTION
    DNA
  • binding
  • RNA
    small molecule
    protein
  • ZBTB43
  • regulation of BDP1 occurs through JNK-mediated alterations in TBP expression
  • role of BDP1 in TFIIIB assembly and pre-initiation complex formation
  • cell & other
    REGULATION
    Other phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB112
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is disadvantageous and unfavorable for progression-free survival in serous ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BDP1 could likely be of clinical relevance as a predictive biomarker in serous ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS