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FLASH GENE
Symbol BDP1 contributors: mct/npt - updated : 14-03-2008
HGNC name B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
HGNC id 13652
Location 5q13.2      Physical location : 70.751.441 - 70.863.649
Synonym name
  • transcription factor-like nuclear regulator
  • putative transcription factor-like nuclear regulator
  • TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1
  • transcription factor IIIB 150
    • Synonym symbol(s) TFC5, TFNR, TAF3B1, KIAA1241, KIAA1689, TFIIIB90, TFIIIB150, TFIIIB, HSA238520
    DNA
    TYPE functioning gene
    STRUCTURE 112.21 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S823 - CCNB1 - RAD17 - OCLN - [GTF2H2 - NAIP - SMN2 - SERF1B ] - (SERF1A - SMN1 - NAIP - GTF2H2 ) - BDP1 - D5S557 - D5S1408 - qter
    Authors Kelter (00)
    Text [centromeric unit], (telomeric unit)
    Physical map
    KENAE 5q13.1 Kenae LOC285653 5q13.1 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein TAF9 5q12 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa RAD17 5q12-q13.1 RAD17 homolog (S. pombe) FLJ30532 5q13.1 hypothetical protein FLJ30532 OCLN 5q13.1 occludin GTF2H2 5q13.1 general transcription factor IIH, polypeptide 2, 44kDa BIRC1 5q13.1 baculoviral IAP repeat-containing 1 SMN1 5q13.1 survival of motor neuron 1, telomeric LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein) LOC389298 5 similar to bA110H4.2 (similar to membrane protein) LOC389299 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC391794 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 PMCHL2 5q13 pro-melanin-concentrating hormone-like 2 BDP1 5q13 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB MCCC2 5q12-q13 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) CART 5q13.1 Homo sapiens cocaine- and amphetamine-regulated transcript (CART), mRNA. MAP1B 5q13 microtubule-associated protein 1B MRPS27 5q13.2 mitochondrial ribosomal protein S27 FLJ12598 5q13.2 hypothetical protein FLJ12598 LOC391795 5 similar to ribosomal protein L10a ZNF366 5q13.1 zinc finger protein 366 LOC389300 5 LOC389300 KPNB2 5p14.2-q22.3 karyopherin (importin) beta 2 LOC115548 5q13.2 hypothetical protein BC014311 LOC134285 5q13.3 hypothetical protein LOC134285 MGC13034 5q13.3 hypothetical protein MGC13034 LOC389301 5 similar to nonhistone chromosomal protein HMG-17 - rat LOC389302 5 LOC389302 FOXD1 5q12-q13 forkhead box D1 BTF3 5p13.2 basic transcription factor 3 LOC220793 5q13.3 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 ANKRA2 5q12-q13 ankyrin repeat, family A (RFXANK-like), 2 FLJ12787 5q13.3 hypothetical protein FLJ12787 PRO1942 5q13.3 hypothetical protein PRO1942 RGNEF 5q13.3 Rho-guanine nucleotide exchange factor
    RNA
    TRANSCRIPTS type messenger
    text short copies maybe spliced, truncated copies or paralogues
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7193 252.8 2254 cerebellum Kelter, Schramm (2000)
    - splicing 4272 155.7 1388 weakly Schramm
  • also called B''
  • lacking exon 15, truncated
    • - splicing 4273 155.6 1372 weakly Schramm (2000)
  • also called B" short
  • remplacement of the 21 last Aas
    • - splicing - 89 796 weakly Kelter (2000)
    lacking exon 15 truncated
    - - 4300 1388 - - Schramm (2000)
    - splicing 4300 1372 - - Schramm (2000)
    replacement of the last 21 amino acids with 5 different amino acids
    39 - 11097 293 2624 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systembreastmammary gland moderately
     female systemuterus  moderately
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular Hydrophilic
    STRUCTURE
    motifs/domains
  • nine repeats of a 55 aa motif rich in serine, lysine, glutamic acid (coded by exon 17)
  • a bipartite nuclear localization signal (NLS)
  • a DNA ligase A1 ATP-dependent binding site
  • a second NLS in the C terminal region
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae TFC7
    homolog to dog BDP1 (67.4 pc)
    homolog to murine Bdp1 (53 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • acting as a transcription factor-like nuclear regulator
  • required for transcription from the Ad2 VAI and human U6RNA polymerase III promotors
    • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the U6 initiation complex
  • subunit of the TFIIIB transcription initiation complex
    • INTERACTION
    DNA
  • binding
    • RNA
    small molecule
    protein
  • ZBTB43
    • cell & other
    REGULATION
    Other phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS