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FLASH GENE
Symbol RAD17 contributors: mct - updated : 30-10-2015
HGNC name RAD17 homolog (S. pombe)
HGNC id 9807
Location 5q13.2      Physical location : 68.665.123 - 68.710.626
Synonym name
  • RF-C activator 1 homolog
  • cell cycle checkpoint protein (RAD17)
  • Synonym symbol(s) RAD24, RAD17sp, CCYC, FLJ41520, R24L
    DNA
    TYPE functioning gene
    STRUCTURE 45.73 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC206227 5q13.1 similar to B-cell lymphoma 9 protein (Bcl-9) (Legless homolog) LOC359819 5q12.3 mitochondrial ribosomal protein L39 pseudogene EEF1B3 5q12-q14 eukaryotic translation elongation factor 1 beta 3 PIK3R1 5q12-q13 phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) SLC30A5 5q12.1 solute carrier family 30 (zinc transporter), member 5 CCNB1 5q11-q12 cyclin B1 CENPH 5p15.2 centromere protein H MRPS36 5q13.3 mitochondrial ribosomal protein S36 CDK7 2p15-pcen cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) KENAE 5q13.1 Kenae LOC285653 5q13.1 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein TAF9 5q12 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa RAD17 5q12-q13.1 RAD17 homolog (S. pombe) FLJ30532 5q13.1 hypothetical protein FLJ30532 OCLN 5q13.1 occludin GTF2H2 5q13.1 general transcription factor IIH, polypeptide 2, 44kDa BIRC1 5q13.1 baculoviral IAP repeat-containing 1 SMN1 5q13.1 survival of motor neuron 1, telomeric LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein) LOC389298 5 similar to bA110H4.2 (similar to membrane protein) LOC389299 5 similar to Beta-glucuronidase precursor (Beta-G1)
    RNA
    TRANSCRIPTS type messenger
    text four alternatively spliced isoforms (Chen 2001)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 splicing 3076 75.7 670 - 2001 11602352
    17 - 3164 75.7 670 - 2001 11602352
    16 splicing 2633 77 681 - 2001 11602352
    16 splicing 2666 57.1 505 - 2001 11602352
    16 - 2592 66 584 - 2001 11602352
    18 - 2972 75.7 670 - 2001 11602352
    18 - 3010 75.7 670 - 2001 11602352
    17 - 2842 75.7 670 - 2001 11602352
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines cancer cell lines (in colon carcinoma)
    fluid/secretion seminoma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • potential a N terminal P-loop binding consensus sequence
  • a Walker B motif
  • HOMOLOGY
    interspecies homolog to yeast S.pombe RAD17
    homolog to yeast S.cerevisiae RAD24
    homolog to murine Rad24
    homolog to murine Rad17
    Homologene
    FAMILY
  • rad17/RAD24 family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • cell cycle G2 checkpoint control gene, required for S-phase and G2/M arrest in response to DNA damage or incomplete DNA replication
  • centrally involved in the activation of cell-cycle checkpoints by genotoxic agents or replication stress
  • phosphorylation-dependent function of RAD17 in an ATR-RAD17-Claspin-CHEK1-signaling cascade that responds to specific replication stress
  • similarly to other human genes involved in checkpoint mechanisms, plays a role in control of tumor growth
  • critical for the ATR-dependent activation of CHEK1 during checkpoint responses
  • exhibiting a distinctive pattern of upregulation followed by subsequent degradation after exposure to UV radiation in primary cells
  • its stabilization prevents the termination of checkpoint signalling, which in turn attenuates the cellular re-entry into cell-cycle progression
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RAD17/RAD3/RAD1, is the 9-1-1 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAD1 (interaction protein-protein in the cell cycle checkpoint machinery)
  • MCM7, a core component of the DNA replication apparatus, is a novel RAD17-interacting protein
  • phosphorylated RAD17 interacts with Claspin and regulates its phosphorylation
  • plays a central role in establishment of the interaction between TOPBP1 and the RAD9A-HUS1-RAD1 complex at stalled replication forks
  • Claspin and RAD17 are reportedly involved in the DNA damage-induced phosphorylation of CHEK1, a hallmark of checkpoint activation
  • RAD9A is loaded by RAD17 onto damaged chromatin
  • USP20 is required for RAD17 protein stability in the steady-state and post DNA damage
  • gain of function mutant TP53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression
  • cell & other
    REGULATION
    Other phosphorylation by ATR is important for genomic stability and restraint of S phase but is not essential for cell survival
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in head and neck cancer, is often due to genomic deletion, and may facilitate genomic instability in head and neck cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS