Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ATIC | contributors: mct - updated : 03-02-2020 |
HGNC name | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
HGNC id | 794 |
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Corresponding disease |
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Location | 2q35 Physical location : 216.176.678 - 216.214.499 | ||
Synonym name | |||
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Synonym symbol(s) | AICARFT, AICAR, IMPCHASE, PURH, HEL-S-70p, FLJ93545 | ||
EC.number | EC 2.1.2.3, 3.5.4.10 |
DNA |
TYPE | functioning gene |
STRUCTURE | 37.82 kb 16 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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motif | repetitive sequence ALU long interspersed repetitive elements |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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HOMOLOGY |
interspecies | homolog to rattus atic |
homolog to chicken purh |
Homologene |
FAMILY | PURH family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,mitochondria | |
intracellular,cytoplasm,cytosolic |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | purine/pyrimidine |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
cell & other |
REGULATION |
Other | ALK-mediated ATIC phosphorylation enhanced its enzymatic activity, dampening the methotrexate-mediated transformylase activity inhibition |
ASSOCIATED DISORDERS |
corresponding disease(s) | AICAR |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |