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FLASH GENE
Symbol ATIC contributors: mct - updated : 03-02-2020
HGNC name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
HGNC id 794
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver    
Endocrineadrenal gland   highly
 pancreas    
Lymphoid/Immunetonsils   highly
Nervousbrain    
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal MGS (methylglyoxal synthetase)-like domain
  • the bifunctional enzyme is found in both prokaryotes and eukaryotes
  • the second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • HOMOLOGY
    interspecies homolog to rattus atic
    homolog to chicken purh
    Homologene
    FAMILY PURH family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis, second last step 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate
  • enhances insulin sensitivity and reverses insulin resistance under several conditions in skeletal muscles
  • potential anti diabetic drug, significantly counteracted the negative effects of beta-hydroxybutyrate (BOH) on insulin action
  • ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-MTOR-S6 K1 signaling
  • bifunctional protein enzyme, catalyzing the last two steps of the de novo purine biosynthetic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • appeared to exert its effect on insulin-mediated glucose uptake by enhancing phosphorylation of the Akt substrate TBC1D4
  • ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with insulin receptor (INSR) internalization
  • ATIC suppresses AMPK activation, thus activates MTOR-S6 K1-S6 signaling and supports growth and motility activity of HCC cells
  • IL7 stimulation induced the phosphorylation of the proteins STIP1, ATIC and HNRNPH, involved in pathways related to survival, proliferation and gene expression, respectively, and increased the phosphorylation of CRKL
  • OSBPL2 was found to interact with ATIC, key activator of AMPK
  • cell & other
    REGULATION
    Other ALK-mediated ATIC phosphorylation enhanced its enzymatic activity, dampening the methotrexate-mediated transformylase activity inhibition
    ASSOCIATED DISORDERS
    corresponding disease(s) AICAR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   inversion    
    inv(2)(p23;q35)in anaplastic large-cell lymphoma
    tumoral fusion      
    fused with ALK in anaplastic large cell lymphoma
    tumoral fusion      
    with ALK in intraosseous inflammatory myofibroblastic tumor of the mandible
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS