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FLASH GENE
Symbol ATIC contributors: mct - updated : 03-02-2020
HGNC name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
HGNC id 794
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2094 - 592 - 1996 8567683
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver    
Endocrineadrenal gland   highly
 pancreas    
Lymphoid/Immunetonsils   highly
Nervousbrain    
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal MGS (methylglyoxal synthetase)-like domain
  • the bifunctional enzyme is found in both prokaryotes and eukaryotes
  • the second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • HOMOLOGY
    interspecies homolog to rattus atic
    homolog to chicken purh
    Homologene
    FAMILY PURH family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis, second last step 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate
  • enhances insulin sensitivity and reverses insulin resistance under several conditions in skeletal muscles
  • potential anti diabetic drug, significantly counteracted the negative effects of beta-hydroxybutyrate (BOH) on insulin action
  • ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-MTOR-S6 K1 signaling
  • bifunctional protein enzyme, catalyzing the last two steps of the de novo purine biosynthetic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • appeared to exert its effect on insulin-mediated glucose uptake by enhancing phosphorylation of the Akt substrate TBC1D4
  • ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with insulin receptor (INSR) internalization
  • ATIC suppresses AMPK activation, thus activates MTOR-S6 K1-S6 signaling and supports growth and motility activity of HCC cells
  • IL7 stimulation induced the phosphorylation of the proteins STIP1, ATIC and HNRNPH, involved in pathways related to survival, proliferation and gene expression, respectively, and increased the phosphorylation of CRKL
  • OSBPL2 was found to interact with ATIC, key activator of AMPK
  • cell & other
    REGULATION
    Other ALK-mediated ATIC phosphorylation enhanced its enzymatic activity, dampening the methotrexate-mediated transformylase activity inhibition
    ASSOCIATED DISORDERS
    corresponding disease(s) AICAR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   inversion    
    inv(2)(p23;q35)in anaplastic large-cell lymphoma
    tumoral fusion      
    fused with ALK in anaplastic large cell lymphoma
    tumoral fusion      
    with ALK in intraosseous inflammatory myofibroblastic tumor of the mandible
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS