basic FUNCTION
| may play a role in adipocyte differentiation and function |
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plays a regulatory role in cell proliferation and PPAR-gamma activation |
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required for beta2-adrenergic receptor (ADRB2) regulation, and is an essential adaptor for ADRB2 ubiquitination |
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essential adaptor that recruits the NEDD4 E3 ligase to mediate ADRB2 ubiquitination |
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functions in a novel regulatory pathway that controls the cell surface adhesion molecule, beta-4 integrin (ITGB4), a protein associated with aggressive tumor behavior |
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functions as a novel regulator of tumor progression in breast cancer because of its effects on ITGB4 internalization and degradation |
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regulator of breast cancer growth and progression that targets ITGB4 for internalization and proteosome dependent degradation |