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FLASH GENE

Symbol

ARRDC3

contributors: mct - updated : 28-02-2017

HGNC name	arrestin domain containing 3
HGNC id	29263

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland           thyroid         Lymphoid/Immune lymph node           thymus         Reproductive female system placenta         female system breast mammary gland     Respiratory respiratory tract trachea       Urinary bladder           kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two PPXY motifs at its C- terminus, which are conserved among other orthologues

HOMOLOGY

interspecies	homolog to murine Arrdc3 (98.1pc)
	homolog to rattus Arrdc3 (98.1pc)

Homologene

FAMILY

arrestin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
text	associated with the plasma membrane, endosomes, lysosomes during endocytosis

basic FUNCTION	may play a role in adipocyte differentiation and function
	plays a regulatory role in cell proliferation and PPAR-gamma activation
	required for beta2-adrenergic receptor (ADRB2) regulation, and is an essential adaptor for ADRB2 ubiquitination
	essential adaptor that recruits the NEDD4 E3 ligase to mediate ADRB2 ubiquitination
	functions in a novel regulatory pathway that controls the cell surface adhesion molecule, beta-4 integrin (ITGB4), a protein associated with aggressive tumor behavior
	functions as a novel regulator of tumor progression in breast cancer because of its effects on ITGB4 internalization and degradation
	regulator of breast cancer growth and progression that targets ITGB4 for internalization and proteosome dependent degradation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with ubiquitin ligase neural precursor development downregulated protein 4 (NEDD4) through two conserved PPXY motifs and recruits NEDD4 to the activated receptor
	binds ITGB4 after ubiquitination, and seems likely to have a role in targeting ITGB4 for degradation)

cell & other

REGULATION

induced by

PPARG agonists, PGJ2, vitamin D3, PMA

Other

up-regulated in differentiating adipocytes

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   represses breast cancer cell proliferation, migration, invasion tumoral     --low   promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal carcinomas (IDCs)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	ARRCD3-ITGB4 pathway is a new therapeutic target in breast cancer

ANIMAL & CELL MODELS