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FLASH GENE

Symbol

ARRDC3

contributors: mct - updated : 28-02-2017

HGNC name	arrestin domain containing 3
HGNC id	29263

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   represses breast cancer cell proliferation, migration, invasion tumoral     --low   promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal carcinomas (IDCs)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	ARRCD3-ITGB4 pathway is a new therapeutic target in breast cancer

ANIMAL & CELL MODELS