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FLASH GENE
Symbol ARID2 contributors: mct - updated : 08-09-2012
HGNC name AT rich interactive domain 2 (ARID, RFX-like)
HGNC id 18037
Location 12q12      Physical location : 46.123.619 - 46.301.819
Synonym name
  • zipzap
    • Synonym symbol(s) P200, BAF200
    DNA
    TYPE functioning gene
    STRUCTURE 178.20 kb     21 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 8466 - 1835 - 2006 16782067
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
    Endocrineneuroendocrinepituitary  moderately
     thyroid   moderately
    Reproductivefemale systembreastmammary gland moderately
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text stem cells, embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ARID domain
  • a nucleosome assembly protein (NAP) domain
    • HOMOLOGY
    interspecies homolog to rattus Arid2 (91.21 pc)
    homolog to murine Arid2 (90.89 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional activation and repression of select genes by chromatin remodeling
  • required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF)
  • may be serving as a transcription co-activator for the regulation of cardiac gene expression
  • tumor suppressor gene that is relatively commonly mutated in hepatocellular carcinoma
  • critical role for ARID2-containing complexes in promoting osteoblast differentiation
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     loss of function
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS