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FLASH GENE
Symbol ARID2 contributors: mct - updated : 08-09-2012
HGNC name AT rich interactive domain 2 (ARID, RFX-like)
HGNC id 18037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ARID domain
  • a nucleosome assembly protein (NAP) domain
    • HOMOLOGY
    interspecies homolog to rattus Arid2 (91.21 pc)
    homolog to murine Arid2 (90.89 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional activation and repression of select genes by chromatin remodeling
  • required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF)
  • may be serving as a transcription co-activator for the regulation of cardiac gene expression
  • tumor suppressor gene that is relatively commonly mutated in hepatocellular carcinoma
  • critical role for ARID2-containing complexes in promoting osteoblast differentiation
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     loss of function
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS