Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ARID2

contributors: mct - updated : 08-09-2012

HGNC name	AT rich interactive domain 2 (ARID, RFX-like)
HGNC id	18037

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	178.20 kb     21 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152641 21 - 8466 NP_689854 - 1835 - 2006 16782067

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately Endocrine neuroendocrine pituitary     moderately   thyroid       moderately Reproductive female system breast mammary gland   moderately   male system testis     highly Respiratory respiratory tract larynx     moderately Urinary bladder       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	stem cells, embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an ARID domain
	a nucleosome assembly protein (NAP) domain

HOMOLOGY

interspecies	homolog to rattus Arid2 (91.21 pc)
	homolog to murine Arid2 (90.89 pc)

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in transcriptional activation and repression of select genes by chromatin remodeling
	required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF)
	may be serving as a transcription co-activator for the regulation of cardiac gene expression
	tumor suppressor gene that is relatively commonly mutated in hepatocellular carcinoma
	critical role for ARID2-containing complexes in promoting osteoblast differentiation

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

binding

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation     loss of function in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS