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FLASH GENE
Symbol ALPP contributors: npt/mct - updated : 28-01-2015
HGNC name alkaline phosphatase, placental (Regan isozyme)
HGNC id 439
Location 2q37.1      Physical location : 233.243.347 - 233.247.597
Synonym name
  • placental alkaline phosphatase
  • alkaline phosphomonoesterase
  • glycerophosphatase
  • Synonym symbol(s) PLAP, PLAP-1 , ALP
    EC.number 3.1.3.1
    DNA
    TYPE functioning gene
    STRUCTURE 4.25 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - CRYG@ - FN1 - ALPP - SAG - D2S55 - D2S3 - qter
    Authors Farrer (92)
    Physical map
    LOC389082 2 similar to archease NCL 2q12-qter nucleolin MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174 ALPP 2q37.1 alkaline phosphatase, placental (Regan isozyme) ALPPL2 2q37 alkaline phosphatase, placental-like 2 LOC391492 2 similar to xce ALPI 2q37.1 alkaline phosphatase, intestinal ECEL1 2q36-q37 endothelin converting enzyme-like 1 LOC389083 2 similar to enterokinase CHRND 2q37 cholinergic receptor, nicotinic, delta polypeptide CHRNG 2q37.1-q37.2 cholinergic receptor, nicotinic, gamma polypeptide TIGD1 2q36.1 tigger transposable element derived 1 EIF4EL3 2q37.3 eukaryotic translation initiation factor 4E-like 3 FLJ13612 TNRC15 2q37.1 trinucleotide repeat containing 15 KCNJ13 2q37 potassium inwardly-rectifying channel, subfamily J, member 13 LOC389084 2 similar to ASCL830 NGEF 2q37 neuronal guanine nucleotide exchange factor NEU2 2q37 sialidase 2 (cytosolic sialidase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2883 57 535 - Kam-Enthorn, Llinas (2005)
    - - 2590 57 530 - Kam-Enthorn
    - - 2700 57 513 - Kam-Millan
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus    
    Reproductivefemale systemplacenta   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • two glycosylation sites
  • zinc-metalloprotein, made of a complex of identical subunits, each subunit containing one active site
  • two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor
  • a peripheral binding site may be involved in the functional specialization of the PLAP isozyme
  • secondary structure N terminal alpha helix
    conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to E.coli Plap
    Homologene
    FAMILY
  • alkaline phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy
  • involved in the intrauterine selection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • Zn2+
  • protein
  • RBM3 has a role in enhancing the transcription of ALPP and BGLAP genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopically expressed by cancer cells, in seminoma
    Susceptibility
  • to abortion
  • to deleterious action of maternal smoke on intrauterine survival and birthweight
  • Variant & Polymorphism other
  • isoform PLAPD increased in spontaneous abortion
  • polymorphisms increasing deleterious action of maternal smoke on intrauterine survival and birthweight in women older than 28 years
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS