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FLASH GENE
Symbol FN1 contributors: mct/npt - updated : 16/10/2008
HGNC name fibronectin 1
HGNC id 3778
Corresponding disease
EDS10 Ehlers-Danlos syndrome, type X
GFND2 glomerulopathy with fibronectin deposits 2
Location 2q35      Physical location : 216.225.180 - 216.300.791
Synonym name
  • cold inducible globulin
  • migration stimulating factor
    • Synonym symbol(s) FN, CIG, FINC, LETS, MSF, GFND2, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 75.61 kb     46 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC200595 2q35 similar to chromosome 20 open reading frame 81 ZNFN1A2 2qter zinc finger protein, subfamily 1A, 2 (Helios) PF20 2q35 PF20 LOC391481 2 similar to Alpha-endosulfine BARD1 2q34-q35 BRCA1 associated RING domain 1 LOC285176 2q35 similar to 60S ribosomal protein L10 (QM protein homolog) ABCA12 2q34 ATP-binding cassette, sub-family A (ABC1), member 12 ATIC 2q35 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase FN1 2q35 fibronectin 1 LOC151575 2q35 similar to MLRQ subunit of the NADH: ubiquinone oxidoreductase complex FLJ10116 2q35 hypothetical protein FLJ10116 PECR 2q35 hypothetical protein FLJ10116 LOC92691 2q35 hypothetical protein BC008604 XRCC5 2q35 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) KIAA1399 2q35 KIAA1399 protein SMARCAL1 2q34-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 RPL37A 2q35 ribosomal protein L37a LOC130700 2q35 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene IGFBP2 2q33-q34 insulin-like growth factor binding protein 2, 36kDa IGFBP5 2q33-q34 insulin-like growth factor binding protein 5 LOC391483 2 similar to ribosomal protein L31 TNP1 2q34-q36 transition protein 1 (during histone to protamine replacement) LOC151363 2q35 hypothetical LOC151363 TNS 2q35-q36 tensin FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    46 - 8815 - 2477 - Kay, Telci (2008)
    47 - 8647 - 2421 - Kay, Telci (2008)
    46 - 8449 - 2355 - Kay, Telci (2008)
    46 - 8374 - 2330 - Kay, Telci (2008)
    44 - 8272 - 2296 - Kay, Telci (2008)
    - - 2402 - 657 - Kay
    44 - 7912 - 2176 - Kay, Telci (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
     mouthtongue  highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion plasma (soluble dimeric form)
    at STAGE
    physiological period embryo, fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P2 adhesive glycoprotein
  • 12 fibronectin type-I domains
  • two fibronectin type-II domains
  • 16 fibronectin type-III domains
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , development , immunity/defense
    text adhesion, migration
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • heparin
    • protein
  • collagen, actin
    • cell & other
  • bind cell surfaces and various compounds including fibrin, DNA
    • REGULATION
    Other degradation by LRP
    ASSOCIATED DISORDERS
    corresponding disease(s) EDS10 , GFND2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cells
    tumoral       gain of function
    up-regulated in germ cells yolk sac tumors
    Susceptibility susceptibility to lung fibrosing alveolitis in systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS