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FLASH GENE
Symbol FN1 contributors: mct/npt - updated : 19-05-2014
HGNC name fibronectin 1
HGNC id 3778
Corresponding disease
EDS10 Ehlers-Danlos syndrome, type X
GFND2 glomerulopathy with fibronectin deposits 2
Location 2q34      Physical location : 216.225.180 - 216.300.791
Synonym name
  • cold inducible globulin
  • migration stimulating factor
  • Synonym symbol(s) FN, CIG, FINC, LETS, MSF, GFND2, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 79.12 kb     46 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC200595 2q35 similar to chromosome 20 open reading frame 81 ZNFN1A2 2qter zinc finger protein, subfamily 1A, 2 (Helios) PF20 2q35 PF20 LOC391481 2 similar to Alpha-endosulfine BARD1 2q34-q35 BRCA1 associated RING domain 1 LOC285176 2q35 similar to 60S ribosomal protein L10 (QM protein homolog) ABCA12 2q34 ATP-binding cassette, sub-family A (ABC1), member 12 ATIC 2q35 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase FN1 2q35 fibronectin 1 LOC151575 2q35 similar to MLRQ subunit of the NADH: ubiquinone oxidoreductase complex FLJ10116 2q35 hypothetical protein FLJ10116 PECR 2q35 hypothetical protein FLJ10116 LOC92691 2q35 hypothetical protein BC008604 XRCC5 2q35 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) KIAA1399 2q35 KIAA1399 protein SMARCAL1 2q34-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 RPL37A 2q35 ribosomal protein L37a LOC130700 2q35 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene IGFBP2 2q33-q34 insulin-like growth factor binding protein 2, 36kDa IGFBP5 2q33-q34 insulin-like growth factor binding protein 5 LOC391483 2 similar to ribosomal protein L31 TNP1 2q34-q36 transition protein 1 (during histone to protamine replacement) LOC151363 2q35 hypothetical LOC151363 TNS 2q35-q36 tensin FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    46 - 8815 - 2477 - 2005 16322219
    47 - 8647 - 2421 - 2005 16322219
    46 - 8449 - 2355 - 2005 16322219
    46 - 8374 - 2330 - 2005 16322219
    44 - 8272 - 2296 - 2005 16322219
    - - 2402 - 657 - 2005 16322219
    44 - 7912 - 2176 - 2005 16322219
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
     mouthtongue  highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion plasma (soluble dimeric form)
    at STAGE
    physiological period embryo, fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P2 adhesive glycoprotein
  • 12 fibronectin type-I domains
  • two fibronectin type-II domains
  • 16 fibronectin type-III domains
  • a gelatin-binding domain (GBD)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text extracellular matrix
    basic FUNCTION
  • involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape
  • it might be a critical molecule produced by T(H)1 cells involved in pathogen eradication
  • upregulates osteoclast activity despite inhibiting osteoclast formation and these effects involve nitric oxide and IL1B signaling
  • laminin and fibronectin may play crucial roles in the control of trophoblast adhesion and invasion, in placentation and angiogenesis
  • glycoprotein involved in cellular adhesion and migration processes
  • O-glycosylated oncofetal fibronectin has a synergistic effect with transforming growth factor (TGFB1) in EMT induction
  • FN1 and WNT7A together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis
  • is a key factor in serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture
  • is essential for endogenous cardiac progenitor cells (CPCs) expansion and repair required for stabilization of cardiac function after myocardial infarction (MI)
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , development , immunity/defense
    text adhesion, migration
    PATHWAY
    metabolism
    signaling
  • SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
  • heparin
  • protein
  • collagen, actin
  • binds BMP1-like proteinases and FN1 is an important determinant of the activity levels of BMP1-like proteinases
  • HAND2 pathway establishes an appropriate environment for cardiac fusion through negative modulation of FN1 levels
  • interaction between the NC4 domain of COL9A1 and FN1 may represent an interaction in cartilage that could contribute to the matrix integrity of the tissue
  • is potentially a critical mediator for TGFB-specific production balance of 2 major proteoglycans, aggrecan and versican, during chondrogenesis
  • synthesis of FN1 is mediated by a transcriptional complex consisting of NFATC1, SP7 and FOS
  • association between EPO and FN1 expression in glomerular mesangial cells
  • RHOA stimulates the production of FN1 by podocytes, specifically testing the role of nuclear factor of activated T cells (NFATC1)
  • NFATC1 mediates RHOA-induced FN1 upregulation in glomerular podocytes
  • interaction between fibronectin (FN1) and collagen
  • FN1 and its major receptor, ITGB1/ITGA5 are required for embryogenesis
  • cell & other
  • bind cell surfaces and various compounds including fibrin, DNA
  • REGULATION
    induced by decreased DICER1 expression that induces FN1 expression via an EGR1-dependent manner
    Other degradation by LRP
    ASSOCIATED DISORDERS
    corresponding disease(s) EDS10 , GFND2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cells
    tumoral       gain of function
    up-regulated in germ cells yolk sac tumors
    tumoral     --over  
    in renal cancer
    Susceptibility susceptibility to lung fibrosing alveolitis in systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
  • FN1 mRNA expression might serve as a marker for renal cell cancer (RCC) aggressiveness, indicating early systemic progression particularly for patients with papillary RCC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    offers crucial molecular insights and promises to develop putative candidate therapeutic interventions in women with ovarian cancer
    ANIMAL & CELL MODELS