| basic FUNCTION
| may be involved in the regulation of gene expression |
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autoimmune regulator gene, transactivating transcription through heteromeric molecular interactions regulated by homomultimerization |
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AIRE regulates gene expression by recruiting components of the transcription complex to specific regions of the genome via interactions with nuclear matrix  |
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promotes the establishment of self-tolerance by regulating gene expression in the thymus |
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with PIAS1 interact functionally to regulate the activities of the target genes of AIRE |
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functions as a transcriptional regulator, and has a central role in the development of immunological tolerance |
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has a critical role in dendritic cells responses to microbial stimuli |
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able to promote ectopic gene expression from chromatin associated with histone modifications characteristic to inactive genes, and of tissue-specific genes from chromatin lacking transcriptionally active histone H3 modifications |
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may be involved in structural changes of larger chromatin regions |
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regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells |
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transcription factor involved in the presentation of tissue-restricted antigens during T-cell development in the thymus |
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transcription factor that induces the expression of a large subset of otherwise strictly tissue restricted antigens in medullary thymic epithelial cells, thereby enabling their presentation to developing T cells for negative selection |
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AIRE requires CDK9 to activate transcription elongation and co-transcriptional processing of target genes |
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has a central role in the transcriptional regulation of self-antigens in medullary thymic epithelial cells, which is necessary for negative selection of autoreactive T cells |
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the pathways behind AIRE-induced apoptosis may be directly linked to the induction of central tolerance in thymus |
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AIRE-induced cellular stress and apoptosis are associated with GAPDH translocation into the nuclei |
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impacts immunological tolerance by regulating the expression of a large set of genes in thymic medullary epithelial cells |
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multidomain protein that performs a fundamental function in the thymus and possibly in the secondary lymphoid organs: the regulation, especially in the sense of activation, of the process of gene transcription in cell lines deputed to the presentation of self-antigens to the maturing T lymphocytes |
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plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells |
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fundamental role of AIRE and promiscuous gene expression (pGE), namely, central tolerance, in the predisposition to autoimmunity of Down syndrome individuals |
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key factor in thymic negative selection of autoreactive T cells by promoting the ectopic expression of tissue-specific genes in the thymic medullary epithelium |
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presence of AIRE can trigger molecular events leading to an altered chromatin landscape and the enhanced transcription of low-expressed genes |
