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FLASH GENE
Symbol TRPC7 contributors: mct/npt/pgu - updated : 17-03-2010
HGNC name transient receptor potential cation channel, subfamily C, member 7
HGNC id 20754
Location 5q31.1      Physical location : 135.548.998 - 135.701.164
Synonym name
  • putative capacitative calcium channel
  • melastatin-like transient receptor potential 7
  • Synonym symbol(s) TRP7
    DNA
    TYPE functioning gene
    STRUCTURE 152.17 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y DCNP1 5q31.2 dendritic cell nuclear protein 1 LOC345607 5q31.2 similar to FLJ00292 protein NEUROG1 5q23-q31 neurogenin 1 CXCL14 5q31 chemokine (C-X-C motif) ligand 14 LOC389330 5 LOC389330 LOC389331 5 LOC389331 LOC153328 5q31.2 similar to CG4995 gene product IL9 5q31.1 interleukin 9 FBXL3B 5q31 F-box and leucine-rich repeat protein 3B LECT2 5q31.1-q32 leukocyte cell-derived chemotaxin 2 TGFBI 5q31.1 transforming growth factor, beta-induced, 68kDa DAMS 5q31.1 SMAD in the antisense orientation MADH5 5q31.1 MAD, mothers against decapentaplegic homolog 5 (Drosophila) LOC389332 5 hypothetical gene supported by BC048329 TRPC7 5q31.2 transient receptor potential cation channel, subfamily C, member 7 LOC391834 5 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC391835 5 similar to Hypothetical protein FLJ20189 SPOCK 5q31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2589 - 746 - 2004 15372022
    11 - 2752 - 801 - 2004 15372022
    12 - 2935 - 862 - 2004 15372022
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbraindiencephalon   
     brainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  highly
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four ANK repeats
  • HOMOLOGY
    interspecies homolog to murine trp7
    intraspecies homolog to TRPC3 and TRPC6, which are also activated by DAG
    Homologene
    FAMILY
  • transient receptor family
  • STRPC subfamily
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text mostly associated to the surface of the spermatogenic cells
    basic FUNCTION
  • forming a receptor-activated non-selective calcium permeant cation channel
  • enhancing calcium influx independently of store depletion
  • may influence sperm motility
  • calcium (Ca2+) and magnesium (Mg2+) conducting channel, during proliferation of human osteoblasts
  • receptor-operated 1,2-diacylglycerol-activated channel in keratinocytes
  • would play important roles in Ca2+ signaling pathway through these characteristic features
  • additional function of TRPC3, and TRPC7 may be to enhance secretion either by affecting transport through the Golgi stack or by increasing fusion at the plasma membrane
  • necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin
  • NFAT signaling pathway
    CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component comprised of homo- or heterotetramers between TRPC3/6/7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by diacylglycerol (DAG), one of the PLC products, having high sequence homology with TRPC3 and TRPC6, which are also activated by DAG
    either Ca(2+) store depletion or phospholipase C activation
    Other expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS