SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,mitochondria,interspace
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| intracellular,cytoplasm,organelle,membrane
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basic FUNCTION
| lipid kinase that phosphorylates multiple substrate |
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phosphorylates monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively |
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multisubstrate lipid kinase that catalyzes the phosphorylation of diacylglycerol (DAG) and monoacylglycerol (with lower affinity) |
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can amplify EGF signaling pathways and may play an important role in the pathophysiology of prostate cancer |
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role of AGK in driving the assembly of the translocator as a result of its effects on phospholipid metabolism in mitochondria |
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AGK plays an important role in promoting proliferation and tumorigenesis in human breast cancer |
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plays an important role in promoting angiogenesis and providing resistance to apoptosis, in hepatocellular carcinoma |
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is a multisubstrate lipid kinase, which is known to be associated with the progression of various types of human cancer |
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AGK might likely play an important role in the viability and motility of glioma cells |
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regulates various cellular processes involved into tumorigenesis and tumor progression |
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mitochondrial lipid kinase that catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to lysophosphatidic acid and phosphatidic acid, respectively |