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FLASH GENE
Symbol AGK contributors: mct/npt - updated : 10-04-2019
HGNC name acylglycerol kinase
HGNC id 21869
ASSOCIATED DISORDERS
corresponding disease(s) CTRCT38 , MTDPS10
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
with ENPP2, were frequently expressed in prostate cancer cells and precancerous high-grade intra-epithelial neoplasia
tumoral     --over  
in hepatocellular carcinoma (HCC)
tumoral     --over  
in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • AGK can be used as an independent prognostic marker for early-stage cervical squamous cell cancer (CSCC)
  • may serve as a novel prognostic biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may represent a novel therapeutic target for HCC
    cancerbrainglioma/neuroblstoma
    attractive therapeutic target for glioma
    cancerreproductivebreast
    may serve as a therapeutic target in breast cancer
    ANIMAL & CELL MODELS