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FLASH GENE
Symbol AGK contributors: mct/npt - updated : 10-04-2019
HGNC name acylglycerol kinase
HGNC id 21869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • lipid kinase that phosphorylates multiple substrate
  • phosphorylates monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively
  • multisubstrate lipid kinase that catalyzes the phosphorylation of diacylglycerol (DAG) and monoacylglycerol (with lower affinity)
  • can amplify EGF signaling pathways and may play an important role in the pathophysiology of prostate cancer
  • role of AGK in driving the assembly of the translocator as a result of its effects on phospholipid metabolism in mitochondria
  • AGK plays an important role in promoting proliferation and tumorigenesis in human breast cancer
  • plays an important role in promoting angiogenesis and providing resistance to apoptosis, in hepatocellular carcinoma
  • is a multisubstrate lipid kinase, which is known to be associated with the progression of various types of human cancer
  • AGK might likely play an important role in the viability and motility of glioma cells
  • regulates various cellular processes involved into tumorigenesis and tumor progression
  • mitochondrial lipid kinase that catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to lysophosphatidic acid and phosphatidic acid, respectively
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the mitochondrial TIM22 protein import complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of AGK in driving the assembly of SLC25A4, SLC25A5, SLC25A6 and, in some circumstances, respiratory-chain complexes as a result of its effects on phospholipid metabolism in mitochondria
  • AGK functions in a kinase-independent manner to maintain the integrity of the TIMM22 complex, where it facilitates the import and assembly of mitochondrial carrier proteins
    • cell & other
    REGULATION
    activated by cardiolipin
    calcium when magnesium concentrations were low
    inhibited by by sphingosine
    calcium when magnesium concentrations were high
    ASSOCIATED DISORDERS
    corresponding disease(s) CTRCT38 , MTDPS10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with ENPP2, were frequently expressed in prostate cancer cells and precancerous high-grade intra-epithelial neoplasia
    tumoral     --over  
    in hepatocellular carcinoma (HCC)
    tumoral     --over  
    in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • AGK can be used as an independent prognostic marker for early-stage cervical squamous cell cancer (CSCC)
  • may serve as a novel prognostic biomarker in breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may represent a novel therapeutic target for HCC
    cancerbrainglioma/neuroblstoma
    attractive therapeutic target for glioma
    cancerreproductivebreast
    may serve as a therapeutic target in breast cancer
    ANIMAL & CELL MODELS