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FLASH GENE

Symbol

ADGRG2

contributors: mct - updated : 19-09-2016

HGNC name	G protein-coupled receptor 64
HGNC id	4516

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CBAVDX X-Linked congenital bilateral absence of vas deferens
Location	Xp22.13      Physical location : -
Synonym name	epididymis-specific protein 6
	He6 receptor
	epididymal- and efferent-ducts-specific adhesion G protein-coupled receptor G2
Synonym symbol(s)	HE6, TM7LN2, FLJ00282, MGC104454, MGC138738, MGC138739, GPR64, EDDM6

DNA

TYPE	functioning gene
STRUCTURE	133.65 kb     28 Exon(s)    single Copie(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001079858 29 splicing 4895 NP_001073327 111 1017 - 2003 12420295 NM_001079860 27 splicing 4829 NP_001073329 109 995 - 2003 12420295 NM_005756 29 splicing 4886 NP_005747 111 1014 - 2003 12420295 NM_001184833 28 splicing 4847 NP_001171762 - 1001 - 2003 12420295 NM_001184834 28 splicing 4742 NP_001171763 - 966 - 2003 12420295 NM_001079859 28 - 4853 NP_001073328 - 1003 - 2003 12420295 NM_001184835 26 - 4781 NP_001171764 - 979 - 2003 12420295 NM_001184837 27 - 4805 NP_001171766 - 987 - 2003 12420295 NM_001184836 27 - 4823 NP_001171765 - 993 - 2003 12420295

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system male genital tract epididymis     Homo sapiens   male system testis     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a GPS domain
	a seven transmembrane domain (7tm_2)

HOMOLOGY

interspecies	homolog to murine Gpr64 (81.71 pc)
	homolog to rattus Gpr64 (81.07 pc)

Homologene

FAMILY	G-protein coupled receptor 2 family
	LN-TM7 subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in spermatogenesis
	orphan receptor regarding its endogenous agonist and signal transduction
	adhesion GPCR ADGRG2 is critically involved in the adhesion and migration of certain breast cancer cells through mechanisms including a non-canonical NFkB pathway
	crucial role of ADGRG2 in human male fertility
	is able to activate G-protein-mediated signal transduction through a tethered agonist sequence located immediately downstream of the GPS domain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP13

cell & other

REGULATION

activated by

auto-proteolytic cleavage of its very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain

ASSOCIATED DISORDERS

corresponding disease(s)

CBAVDX

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in Ewing sarcomas (ES)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS