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FLASH GENE
Symbol ADGRG2 contributors: mct - updated : 19-09-2016
HGNC name G protein-coupled receptor 64
HGNC id 4516
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GPS domain
  • a seven transmembrane domain (7tm_2)
    • HOMOLOGY
    interspecies homolog to murine Gpr64 (81.71 pc)
    homolog to rattus Gpr64 (81.07 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • LN-TM7 subfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in spermatogenesis
  • orphan receptor regarding its endogenous agonist and signal transduction
  • adhesion GPCR ADGRG2 is critically involved in the adhesion and migration of certain breast cancer cells through mechanisms including a non-canonical NFkB pathway
  • crucial role of ADGRG2 in human male fertility
  • is able to activate G-protein-mediated signal transduction through a tethered agonist sequence located immediately downstream of the GPS domain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP13
    • cell & other
    REGULATION
    activated by auto-proteolytic cleavage of its very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain
    ASSOCIATED DISORDERS
    corresponding disease(s) CBAVDX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ewing sarcomas (ES)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS