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FLASH GENE
Symbol ADGRG2 contributors: mct - updated : 19-09-2016
HGNC name G protein-coupled receptor 64
HGNC id 4516
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 splicing 4895 111 1017 - 2003 12420295
27 splicing 4829 109 995 - 2003 12420295
29 splicing 4886 111 1014 - 2003 12420295
28 splicing 4847 - 1001 - 2003 12420295
28 splicing 4742 - 966 - 2003 12420295
28 - 4853 - 1003 - 2003 12420295
26 - 4781 - 979 - 2003 12420295
27 - 4805 - 987 - 2003 12420295
27 - 4823 - 993 - 2003 12420295
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemmale genital tractepididymis   Homo sapiens
 male systemtestis  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GPS domain
  • a seven transmembrane domain (7tm_2)
  • HOMOLOGY
    interspecies homolog to murine Gpr64 (81.71 pc)
    homolog to rattus Gpr64 (81.07 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • LN-TM7 subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in spermatogenesis
  • orphan receptor regarding its endogenous agonist and signal transduction
  • adhesion GPCR ADGRG2 is critically involved in the adhesion and migration of certain breast cancer cells through mechanisms including a non-canonical NFkB pathway
  • crucial role of ADGRG2 in human male fertility
  • is able to activate G-protein-mediated signal transduction through a tethered agonist sequence located immediately downstream of the GPS domain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP13
  • cell & other
    REGULATION
    activated by auto-proteolytic cleavage of its very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain
    ASSOCIATED DISORDERS
    corresponding disease(s) CBAVDX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ewing sarcomas (ES)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS