Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ADAMTS17

contributors: mct - updated : 28-11-2009

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 17
HGNC id	17109

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	WMSL Weill-Marchesani-like syndrome
Location	15q26.3      Physical location : 100.511.642 - 100.882.183
Synonym name	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
Synonym symbol(s)	FLJ32769, FLJ16363, ADAM-TS17
EC.number	3.4.24.-

DNA

TYPE	functioning gene
STRUCTURE	370.54 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_139057 22 - 6331 NP_620688 118.3 1095 lung, brain, whole eye, and retina showed high expression 2002 11867212 variant 2 16 - - isoform 2 - 502 lung, brain, whole eye, and retina showed high expression, but in the kidney, bone marrow, and skeletal muscle, weakly 2009 19836009 also called ADAMTS17S

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Homo sapiens Nervous brain       highly Homo sapiens Respiratory lung       highly Homo sapiens Urinary kidney       moderately Homo sapiens Visual eye retina     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one metalloproteinase domain
	one disintegrin-like domain
	one thrombospondin type 1 (TS) motif

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to C.elegans R166.5

intraspecies

homolog to ADAMTS19

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	zinc-dependent proteases which play important roles in a variety of normal and pathological conditions, including arthritis and cancer
	may be playing a role in crystalline lens zonules and connective tissue formation
	might play more of a structural role in the assembly or integrity of ECM, similar to what was proposed for ADAMTSL4

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

WMSL

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the synovium and cartilage of osteoarthritis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS