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FLASH GENE
Symbol ADAMTS17 contributors: mct - updated : 28-11-2009
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 17
HGNC id 17109
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one metalloproteinase domain
  • one disintegrin-like domain
  • one thrombospondin type 1 (TS) motif
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans R166.5
    intraspecies homolog to ADAMTS19
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • zinc-dependent proteases which play important roles in a variety of normal and pathological conditions, including arthritis and cancer
  • may be playing a role in crystalline lens zonules and connective tissue formation
  • might play more of a structural role in the assembly or integrity of ECM, similar to what was proposed for ADAMTSL4
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WMSL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the synovium and cartilage of osteoarthritis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS