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FLASH GENE
Symbol ADAMTS17 contributors: mct - updated : 28-11-2009
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 17
HGNC id 17109
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately Homo sapiens
Nervousbrain   highly Homo sapiens
Respiratorylung   highly Homo sapiens
Urinarykidney   moderately Homo sapiens
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one metalloproteinase domain
  • one disintegrin-like domain
  • one thrombospondin type 1 (TS) motif
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans R166.5
    intraspecies homolog to ADAMTS19
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • zinc-dependent proteases which play important roles in a variety of normal and pathological conditions, including arthritis and cancer
  • may be playing a role in crystalline lens zonules and connective tissue formation
  • might play more of a structural role in the assembly or integrity of ECM, similar to what was proposed for ADAMTSL4
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WMSL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the synovium and cartilage of osteoarthritis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS