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FLASH GENE

Symbol

ABR

contributors: mct - updated : 21-05-2011

HGNC name	active BCR-related gene
HGNC id	81

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.3      Physical location : 906.759 - 1.090.616
Synonym symbol(s)	FLJ45954, MDB

DNA

TYPE	functioning gene
STRUCTURE	183.86 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - PFN1 - PAFAH1B1 - CRK - ABR - cen
Authors	Morris (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001159746 23 - 5603 - 822 - 1995 7479768 NM_021962 23 - 5300 - 859 - 1995 7479768

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens Lymphoid/Immune macrophage Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to BCR

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	BCR and its close relative active BCR-related (ABR) localize at excitatory synapses

basic FUNCTION	ABR and BCR are the only GTPase-activating proteins to date that specifically negatively regulate Rac function in primary macrophages
	GTPase-activating protein for the small GTPase Rac
	BCR and ABR cooperate in negatively regulating acute inflammatory responses
	BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

directly interact with DLG4, an abundant postsynaptic scaffolding protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS