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FLASH GENE
Symbol ABR contributors: mct - updated : 21-05-2011
HGNC name active BCR-related gene
HGNC id 81
Location 17p13.3      Physical location : 906.759 - 1.090.616
Synonym symbol(s) FLJ45954, MDB
DNA
TYPE functioning gene
STRUCTURE 183.86 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - PFN1 - PAFAH1B1 - CRK - ABR - cen
Authors Morris (95)
Physical map
RPH3AL 17p13.3 rabphilin 3A-like (without C2 domains) KPNA2 17q23.1-q23.3 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) LOC390819 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388442 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388449 17 LOC388449 LOC388450 17 similar to Ethanolamine-phosphate cytidylyltransferase (Phosphorylethanolamine transferase) (CTP:phosphoethanolamine cytidylyltransferase) LOC388451 17 hypothetical gene supported by AL137626; NM_016538 LOC388452 17 hypothetical gene supported by BC012327; NM_002359 LOC388314 17 LOC388314 LOC388315 17 hypothetical gene supported by AK128660 MGC45871 17p13 hypothetical protein MGC45871 LOC388316 17 hypothetical gene supported by AK056323 FLJ10979 17p13.3 hypothetical protein FLJ10979 CT120 17p13.3 membrane protein expressed in epithelial-like lung adenocarcinoma GEMIN4 17p13 gem (nuclear organelle) associated protein 4 LOC339253 17p13.3 similar to endozepine-like protein CGI-150 17p13.3 CGI-150 protein FLJ10581 17p13.3 putative RNA methyltransferase NXN 17p13.3 nucleoredoxin TIMM22 17p13 translocase of inner mitochondrial membrane 22 homolog (yeast) ABR 17p13.3 active BCR-related gene MRPL14P1 17p13.3 active BCR-related gene LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 5603 - 822 - 1995 7479768
23 - 5300 - 859 - 1995 7479768
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to BCR
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text BCR and its close relative active BCR-related (ABR) localize at excitatory synapses
basic FUNCTION
  • ABR and BCR are the only GTPase-activating proteins to date that specifically negatively regulate Rac function in primary macrophages
  • GTPase-activating protein for the small GTPase Rac
  • BCR and ABR cooperate in negatively regulating acute inflammatory responses
  • BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interact with DLG4, an abundant postsynaptic scaffolding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS