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FLASH GENE
Symbol CRK contributors: mct - updated : 21-05-2011
HGNC name v-crk sarcoma virus CT10 oncogene homolog (avian)
HGNC id 2362
Location 17p13.3      Physical location : 1.325.459 - 1.359.544
Synonym name
  • avian sarcoma virus CT10 (v-crk) oncogene homolog
  • adapter molecule crk
  • CT10 regulator of kinase
  • Synonym symbol(s) CRKII, p38
    DNA
    TYPE functioning gene
    STRUCTURE 34.09 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status confirmed
    Physical map
    TIMM22 17p13 translocase of inner mitochondrial membrane 22 homolog (yeast) ABR 17p13.3 active BCR-related gene MRPL14P1 17p13.3 active BCR-related gene LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide CRK 17p13.3 v-crk sarcoma virus CT10 oncogene homolog (avian) MYO1C 17p13.3-p13.2 myosin IC SKIP 17p13 myosin IC PITPN 17p13.3 phosphotidylinositol transfer protein MGC34680 17p13.3 hypothetical protein MGC34680 RILP 17p13.3 hypothetical protein MGC34680 SCARF1 17p13.3 scavenger receptor class F, member 1 PRPF8 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast) LOC388317 17 LOC388317 MGC14376 17p13.3 hypothetical protein MGC14376 LOC388318 17 LOC388318 FLJ33817 17p13.3 hypothetical protein FLJ33817 SERPINF2 17p13 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 SERPINF1 17p13.3 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 KIAA1936 17p13.3 KIAA1936 protein RPA1 17p13.3 replication protein A1, 70kDa NGRH2 LOC388319 17 LOC388319 DPH2L1 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) OVCA2 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) HIC1 17p13.3 hypermethylated in cancer 1 C17orf31 17p13.3 chromosome 17 open reading frame 31
    RNA
    TRANSCRIPTS type messenger
    text two transcripts,three isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 2245 28 204 - 1992 1630456
  • also called CRK-I
  • one SH2, one SH3 domain
  • 3 splicing 2415 40 304 - 1992 1630456
  • also called CRK-II
  • 170 C terminal AA, one SH2, two SH3 domains
  • - - - 42 - lung 1992 1630456
    170 C terminal AA, one SH2, two SH3 domains
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     mouth   highly
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal SH2 domain functioning as a positive regulator of transformation
  • C-terminal SH3 domain functioning as a negative regulator of transformation
  • HOMOLOGY
    interspecies homolog to avian sarcoma virus CT10 (v-crk)
    Homologene
    FAMILY
  • adapter protein family
  • CATEGORY adaptor , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocolizing with DOCK1 and ELMO1 to membrane ruffles
  • significant percentage of the total endogenous CRK partitions in the nucleus in mammalian cells, where it forms distinct complexes with DOCK1, WEE1, and ABL1
  • basic FUNCTION
  • adaptor protein, involved in cell growth and motility
  • involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4
  • playing a crucial role in the aggressiveness of human synovial sarcoma
  • play a critical role in the breakdown of adherens junctions and the spreading of sheets of epithelial cells
  • have both cytosolic and nuclear functions
  • its nuclear compartmentalization antagonizes its cytoskeletal functions and assign a proapoptotic role to the nuclear pool of CRK
  • effector molecule for Rac1 activation that regulates cell motility
  • regulates cell migration, morphogenesis, invasion, phagocytosis, and survival
  • CRK and CRKL adaptor proteins play important roles in numerous signaling pathways, bridging tyrosine kinase substrates to downstream signaling effectors by virtue of their phosphotyrosine-binding SH2 domains and their effector-binding SH3 domains
  • CRK-MYO1C interaction, which modulates membrane dynamics by regulating RAC1 activity, is crucial for cell adhesion and spreading
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility,in the late steps of apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GRB2, ELMO1
  • activating RAC1
  • interacting with PAFAH1B1
  • SH2-SH3 adaptor protein CRK is an essential target of GIT2 inhibition
  • with CRKL have been proposed to interact with tyrosine phosphorylated DAB1 to mediate downstream events in the Reelin pathway
  • interaction with DOK7, and CRKL (critical role for CRK and CRKL downstream from DOK7 in presynaptic and postsynaptic differentiation)(
  • interaction with SOS1 (have a surprising negative role for ABL kinases in CRK transformation)
  • cell & other
    REGULATION
    Other regulated by GRF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral squamous cell carcinomas, tightly associated with an aggressive phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    could be a potential molecular target of gene therapy by RNAi-targeting in oral squamous cell carcinoma
    ANIMAL & CELL MODELS