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FLASH GENE

Symbol

SLC4A4

contributors: mct - updated : 20-08-2015

HGNC name	solute carrier family 4, sodium bicarbonate cotransporter, member 4
HGNC id	11030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	(NBCe1&
	8722;/&
	8722; mice) have a severe phenotype, severe metabolic acidosis, growth retardation, reduced plasma Na+, hyperaldosteronism, splenomegaly, intestinal obstructions, and die before weaning , and also are described as having an abnormal dentition with “chalk-white” and “brittle” enamel
	mice lacking NBCe1 have enamel abnormalities