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FLASH GENE

Symbol

SLC4A4

contributors: mct - updated : 20-08-2015

HGNC name	solute carrier family 4, sodium bicarbonate cotransporter, member 4
HGNC id	11030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

RTA2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   associated with unfavorable prognosis in Colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of Colorectal cancer
	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
Therapy target

ANIMAL & CELL MODELS

	(NBCe1&
	8722;/&
	8722; mice) have a severe phenotype, severe metabolic acidosis, growth retardation, reduced plasma Na+, hyperaldosteronism, splenomegaly, intestinal obstructions, and die before weaning , and also are described as having an abnormal dentition with “chalk-white” and “brittle” enamel
	mice lacking NBCe1 have enamel abnormalities