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| mice with a keratinocyte-restricted deletion of the Cdc42 gene were born without obvious defects, but showed highly impaired hair coat development  | |
conditionally deletion of Cdc42 gene in telencephalic neural progenitors from mouse embryos abolishes the apical localization of PAR6, aPKC, E-cadherin, beta-catenin, and Numb proteins in the neuroepithelium, and severely impairs the extension of nestin-positive radial fibers |
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brain and neuronal development are severely disrupted in Cdc42-deficient mice |
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mice with podocyte-specific deletion of Cdc42 had severe proteinuria, podocyte foot process effacement, and glomerulosclerosis beginning as early as 10 days of age |
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mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth |
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deletion of Cdc42 in mice could lead to increased adipocyte differentiation and decreased bone formation |