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Symbol CDC42 contributors: mct - updated : 19-06-2018
HGNC name cell division cycle 42 (GTP binding protein, 25kDa)
HGNC id 1736
  • mice with a keratinocyte-restricted deletion of the Cdc42 gene were born without obvious defects, but showed highly impaired hair coat development
  • conditionally deletion of Cdc42 gene in telencephalic neural progenitors from mouse embryos abolishes the apical localization of PAR6, aPKC, E-cadherin, beta-catenin, and Numb proteins in the neuroepithelium, and severely impairs the extension of nestin-positive radial fibers
  • brain and neuronal development are severely disrupted in Cdc42-deficient mice
  • mice with podocyte-specific deletion of Cdc42 had severe proteinuria, podocyte foot process effacement, and glomerulosclerosis beginning as early as 10 days of age
  • mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth
  • deletion of Cdc42 in mice could lead to increased adipocyte differentiation and decreased bone formation