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Symbol CDC42 contributors: mct - updated : 19-06-2018
HGNC name cell division cycle 42 (GTP binding protein, 25kDa)
HGNC id 1736
corresponding disease(s) MTCMR
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancers
Susceptibility to osteoporosis
Variant & Polymorphism SNP increasing the risk of osteoporosis
Candidate gene for holoprosencephaly
Therapy target
ZCL278 is a small molecule that specifically targets CDC42–ITSN1 interaction and inhibits CDC42-mediated cellular processes, thus providing a tool for research of CDC42 subclass of Rho GTPases in pathogenesis, such as cancer and neurological disorders
miscelleaneousurinarychronic kidney disease
maintaining necessary CDC42 would be one potent way to prevent proteinuria kidney diseases
  • mice with a keratinocyte-restricted deletion of the Cdc42 gene were born without obvious defects, but showed highly impaired hair coat development
  • conditionally deletion of Cdc42 gene in telencephalic neural progenitors from mouse embryos abolishes the apical localization of PAR6, aPKC, E-cadherin, beta-catenin, and Numb proteins in the neuroepithelium, and severely impairs the extension of nestin-positive radial fibers
  • brain and neuronal development are severely disrupted in Cdc42-deficient mice
  • mice with podocyte-specific deletion of Cdc42 had severe proteinuria, podocyte foot process effacement, and glomerulosclerosis beginning as early as 10 days of age
  • mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth
  • deletion of Cdc42 in mice could lead to increased adipocyte differentiation and decreased bone formation