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FLASH GENE

Symbol

LMCD1

contributors: mct - updated : 27-09-2016

HGNC name	LIM and cysteine-rich domains 1
HGNC id	6633

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       are potential oncogenic events in hepatocellular metastasis to promote cell migration through the RAC1-signaling pathway constitutional       gain of function significantly upregulated in several models of cardiac hypertrophy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

adult transgenic mice with cardiac-restricted overexpression of Lmcd1, despite normal cardiac function, displayed significant cardiac hypertrophy, again accompanied by induction of hypertrophic marker genes