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FLASH GENE
Symbol LMCD1 contributors: mct - updated : 27-09-2016
HGNC name LIM and cysteine-rich domains 1
HGNC id 6633
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1757 - 365 - 2012 21996735
5 - 1501 - 253 - 2012 21996735
5 - 1668 - 292 - 2012 21996735
5 - 2261 - 247 - 2012 21996735
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrineparathyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domain at the N terminus region
  • two LIM/double zinc finger motifs with regular spacing at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in DNA protein protein interaction during muscle development
  • represses GATA6 activation of both lung and cardiac tissue-specific promoters
  • is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding
  • plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway
  • may play an important role in regulating hypertrophic process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GATA-LIM interaction between GATA6 and LMCD1/dyxin
  • is a novel LIM domain protein acting as a transcriptional cofactor with GATA transcription factors
  • is a DUX4 partner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    are potential oncogenic events in hepatocellular metastasis to promote cell migration through the RAC1-signaling pathway
    constitutional       gain of function
    significantly upregulated in several models of cardiac hypertrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • adult transgenic mice with cardiac-restricted overexpression of Lmcd1, despite normal cardiac function, displayed significant cardiac hypertrophy, again accompanied by induction of hypertrophic marker genes