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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PRAME

contributors: mct - updated : 27-10-2015

HGNC name	preferentially expressed antigen in melanoma
HGNC id	9336

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   by hypermethylation in a variety of cancers, confering growth or survival advantages by antagonizing RAR signaling tumoral     --over   in acute myeloid leukemia tumoral     --other   aberrantly expressed in chronic lymphoproliferative disorders tumoral     --low   in acute myeloblastic leukaemias that carried the chromosomal translocation t(8;21), which fuses the genes AML1 and ETO tumoral     --over   associates with clinicopathologic markers of poor outcome in head and neck cancer and might identify potential candidates with pre-cancerous lesions for chemoprevention with retinoids tumoral     --over   in the vast majority of myxoid liposarcomas, and their high-level expression correlated with tumour grade and poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	marker for differentiating serous carcinoma from malignant mesothelioma
Therapy target
	System Type Disorder Pubmed cancer hemopathy   potential target for therapy in chronic lymphoproliferative disorders cancer hemopathy   target for both prognostic and therapeutic applicationsin leukemia

ANIMAL & CELL MODELS