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FLASH GENE
Symbol PRAME contributors: mct - updated : 27-10-2015
HGNC name preferentially expressed antigen in melanoma
HGNC id 9336
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Endocrineadrenal gland   highly
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines myeloma cell lines, many melanomas, small cell lung carcinoma, head and neck tumor
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a cluster of basic residues
  • a cysteine motif
  • seven LRR (leucine-rich) repeats
  • HOMOLOGY
    interspecies homolog to Drosophila npfr1
    homolog to C.elegans T20H4.4
    Homologene
    FAMILY MAPE family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • tumor antigen recognized by cytolytic T lymphocytes
  • acting as a dominant repressor of RAR signaling
  • plays an important role in disease progression in acute leukemia
  • role for the PRAME ubiquitin ligase complex in NFY-mediated transcriptional regulation
  • plays an important role in cell proliferation and disease progression in osteosarcoma
  • PRAME is upregulated by signalling pathways that are activated in response to infection/inflammation, and its product may have dual functions as a histone-binding protein, and in directing ubiquitylation of target proteins for processing in the Golgi
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text tumor antigen
    PATHWAY
    metabolism
    signaling
    a component
  • BC-box subunit of a Cullin2-based E3 ubiquitin ligase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • gonococcal OPA protein
  • binds to RAR in the presence of RA, preventing ligand-induced receptor activation and target gene transcription through recruitment of Polycomb proteins
  • PRAME is a substrate recognition subunit of a CUL2-based E3 ubiquitin ligase
  • link between the oncoprotein PRAME and the conserved EKC complex and support a role for both complexes in the same pathways
  • PRAME associates with EELOB and ELOC, components of Cullin E3 ubiquitin ligase complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypermethylation in a variety of cancers, confering growth or survival advantages by antagonizing RAR signaling
    tumoral     --over  
    in acute myeloid leukemia
    tumoral     --other  
    aberrantly expressed in chronic lymphoproliferative disorders
    tumoral     --low  
    in acute myeloblastic leukaemias that carried the chromosomal translocation t(8;21), which fuses the genes AML1 and ETO
    tumoral     --over  
    associates with clinicopathologic markers of poor outcome in head and neck cancer and might identify potential candidates with pre-cancerous lesions for chemoprevention with retinoids
    tumoral     --over  
    in the vast majority of myxoid liposarcomas, and their high-level expression correlated with tumour grade and poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • marker for differentiating serous carcinoma from malignant mesothelioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential target for therapy in chronic lymphoproliferative disorders
    cancerhemopathy 
    target for both prognostic and therapeutic applicationsin leukemia
    ANIMAL & CELL MODELS