Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
by hypermethylation in a variety of cancers, confering growth or survival advantages by antagonizing RAR signaling |
tumoral
|  
|  
| --over
|  
|
in acute myeloid leukemia |
tumoral
|  
|  
| --other
|  
|
aberrantly expressed in chronic lymphoproliferative disorders |
tumoral
|  
|  
| --low
|  
|
in acute myeloblastic leukaemias that carried the chromosomal translocation t(8;21), which fuses the genes AML1 and ETO |
tumoral
|  
|  
| --over
|  
|
associates with clinicopathologic markers of poor outcome in head and neck cancer and might identify potential candidates with pre-cancerous lesions for chemoprevention with retinoids |
tumoral
|  
|  
| --over
|  
|
in the vast majority of myxoid liposarcomas, and their high-level expression correlated with tumour grade and poor prognosis |