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Symbol KLK11 contributors: mct - updated : 16-04-2020
HGNC name kallikrein-related peptidase 11
HGNC id 6359
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in advanced and more aggressive prostate tumors, with up-regulation of TMPRSS2 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness
tumoral     --other  
expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP3
tumoral     --over  
increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer
tumoral       gain of function
in colorectal tumors
Variant & Polymorphism
Candidate gene
  • KLK11 mRNA expression is a novel and independent biomarker in laryngeal cancer for diagnostic and prognostic purposes
  • KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
  • potential independent prognostic marker for gastric carcinoma
  • high KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype
  • potential biomarker for poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
  • Therapy target