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FLASH GENE
Symbol KLK11 contributors: mct - updated : 16-04-2020
HGNC name kallikrein-related peptidase 11
HGNC id 6359
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1207 - 250 brain (hippocampus) 1998 9765601
6 splicing 1289 - 282 prostate 1998 9765601
6 - 1195 - 250 - 1998 9765601
6 - 1282 - 275 - 1998 9765601
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Nervousbraindiencephalonhypothalamus highly
 brainhindbraincerebellum  
Reproductivefemale systembreast  highly Homo sapiens
 male systemprostate  highly
Urinarykidneytubule  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsecretoryglandular  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines prostate cancer cell lines (only variant 1)
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic region
  • one signal peptide
  • three key aminoacids essential for serine protease activity
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein-related family of proteases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • multifunctinal protease cleaving several substrates for kallikrein and trypsin
  • involved in normal physiology processes in bronchus
  • estrogen-sensitive kallikreins with KLK14, and KLK10, all synergistically enhanced and upregulated by androgens in breast cancer cells via a membrane bound androgen receptor
  • KLK3, KLK4, KLK11, and KLK2, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process
  • KLK11 played a key role in inhibiting esophageal squamous cell carcinoma (ESCC) carcinogenesis and progression
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of KLK proteolytic cascade with KLK1 and KLK3, activated by KLK14
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced and more aggressive prostate tumors, with up-regulation of TMPRSS2 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness
    tumoral     --other  
    expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP3
    tumoral     --over  
    increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer
    tumoral       gain of function
    in colorectal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLK11 mRNA expression is a novel and independent biomarker in laryngeal cancer for diagnostic and prognostic purposes
  • KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
  • potential independent prognostic marker for gastric carcinoma
  • high KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype
  • potential biomarker for poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
  • Therapy target
    ANIMAL & CELL MODELS