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FLASH GENE

Symbol

CPLX2

contributors: mct/pgu - updated : 07-05-2015

HGNC name	complexin 2
HGNC id	2310

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to schizophrenia

Variant & Polymorphism SNP	six single-nucleotide polymorphisms, distributed over the whole CPLX2 gene, were found to be highly associated with current cognition of schizophrenic subjects but only marginally with premorbid intelligence

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     potentially important therapeutic target for the future treatment of neurologic and psychiatric illnesses

ANIMAL & CELL MODELS

	in Cplx2 -null mutant mice, prominent cognitive loss of function was obtained only in combination with a minor brain lesion applied during puberty, modeling a clinically relevant environmental risk ("second hit") for schizophrenia