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FLASH GENE
Symbol CPLX2 contributors: mct/pgu - updated : 07-05-2015
HGNC name complexin 2
HGNC id 2310
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
highly charged protein, rich in Glu, Asp, Lys, Arg
HOMOLOGY
interspecies homolog to murine Cplx2
Homologene
FAMILY
  • complexin/synaphin family
  • SNARE complex-binding proteins family
    • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • colocalized with VAMP 2 along the apical plasma membrane following cholecystokinin-8 stimulation
    • basic FUNCTION
  • paying a role in synaptic vesicle exocytosis
  • presynaptic protein that modulate neurotransmitter release and are used as markers of inhibitory synapses
  • regulate the size of the primed vesicle pools and have a positive role in Ca(2+)-triggered exocytosis (
  • can regulates degranulation by interacting with the SNARE complex containing syntaxin-3
  • regulate neurotransmitter release by playing a crucial role in triggering fast exocytosis at the synapse (
  • functional role outside the nervous system and it participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis in pancreas (
  • likely key modulator of synaptic activity at the level of astrocytes
  • role of CPLX1 and CPLX2 in facilitating vesicle priming, suggesting that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels
  • presynaptic proteins CPLX1 and CPLX2 differentially influence cognitive function in early and late stages of Alzheimer disease
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling neurotransmission
    late step in Ca2+ dependent neurotransmitter release regulating a step immediately preceding vesicle function
    a component component of exocytic core complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to syntaxin within the SNAP receptor (SNARE) core complex, promoting its oligomerization, essential for synaptic vesicle exocytosis
  • CPLX1, CPLX2 facilitate and inhibit neurotransmitter release through distinct domains, and their function was proposed to be coupled to the Ca(2+) sensor synaptotagmin-1 (SYT1)
  • bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes
  • interact with vesicle-associated membrane protein (VAMP2), syntaxins 3 and 4, but not with VAMP8 or syntaxin 2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP
  • six single-nucleotide polymorphisms, distributed over the whole CPLX2 gene, were found to be highly associated with current cognition of schizophrenic subjects but only marginally with premorbid intelligence
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    potentially important therapeutic target for the future treatment of neurologic and psychiatric illnesses
    ANIMAL & CELL MODELS
  • in Cplx2 -null mutant mice, prominent cognitive loss of function was obtained only in combination with a minor brain lesion applied during puberty, modeling a clinically relevant environmental risk ("second hit") for schizophrenia