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FLASH GENE

Symbol

NEU3

contributors: mct/pgu - updated : 24-06-2015

HGNC name	sialidase 3 (membrane sialidase)
HGNC id	7760

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancers, leading to apoptosis suppression tumoral     --over   in colon cancer (epithelial cells), resulting in inhibition of apoptosis accompanied by increased BCL2 and decreased caspase expression tumoral     --over   in many types of cancers including colon and renal carcinomas and suppresses apoptosis of cancer cells constitutional     --over   significantly enhances cell resistance to hypoxia, whereas stable silencing of the enzyme renders cells more susceptible to apoptosis constitutional     --low   in sperm of some male idiopathic infertility cases

Susceptibility

Variant & Polymorphism

Candidate gene	could represent a new potent biomarker in childhood ALL, to assess the efficacy of therapeutic protocols and to rapidly identify an eventual relapse
Marker
Therapy target
	System Type Disorder Pubmed cancer     siRNAs targeting this protein could have utility for gene-based therapy of cancer cancer     may be a potential target for cancer diagnosis and therapy

ANIMAL & CELL MODELS