SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus
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| intracellular,nuclear envelope,int
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text
| cholesterol and lipid enriched microdomain lipid rafts |
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besides its localization at the plasma membrane, is present in intracellular structures at least partially represented by a subset of the endosomal compartment |
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detected both in the cytosol and nucleus |
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located in the inner membrane of nuclear envelope |
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NEU1 and NEU3 are present on erythrocyte plasma membrane |
basic FUNCTION
| key enzyme for ganglioside degradation, hydrolyzing gangliosides |
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functions as a caveolin-related signaling molecule within caveolin-rich microdomains |
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hving a critical regulatory function on the sialoglycosphingolipid pattern of the cell membrane, with an anti-apoptotic function, especially in cancer cells |
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able to mobilize to membrane ruffles in response to growth stimuli and activate the RAC1 signaling by co-localization with RAC1, leading to increased cell motility |
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differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signaling |
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modulates cell-surface biological events and plays a pivotal role in different cellular processes, including cell adhesion, recognition and differentiation |
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modulates the ganglioside content of adjacent cells with special regard to GM3 concentration, thus governing the cell-to-cell signaling program required for skeletal muscle differentiation |
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key enzyme for the extralysosomal catabolism of gangliosides |
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membrane-associated enzyme that cleaves glycolipid substrates |
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NEU1 restrains endothelial cell migration, whereas NEU3 does not |
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physiological role in protecting cells from hypoxic stress, suggesting potential new directions in the development of therapeutic strategies against ischemic diseases, particularly of the cerebro-cardiovascular system |
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besides the already reported indirect EGFR activation through GM3, sialidase NEU3 could also play a role on EGFR activation through its desialylation |