Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

MED12

contributors: mct - updated : 09-07-2018

HGNC name	mediator complex subunit 12
HGNC id	11957

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FGS1 , LJFS1 , OHDOX

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in uterine leiomyomas tumoral somatic mutation       in prostate cancer tumoral germinal mutation       may likely contribute to chronic lymphocytic leukaemia (CLL) pathogenesis by activating NOTCH signalling tumoral somatic mutation       in 60p100 of breast fibroadenomas (FAs)

Susceptibility

Variant & Polymorphism

Candidate gene	for schizophrenia
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer potential therapeutic target in Alzheimer disease

ANIMAL & CELL MODELS

med12-deficient zebrafish embryos showed defects in brain, neural crest, and kidney development and do not survive beyond 1 week after fertilization