basic FUNCTION
| involved in the regulated transcription of nearly all RNA polymerase II-dependent genes |
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acts as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and general transcription factors |
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coactivator for nuclear receptors |
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playing a regulatory role in vertebrate neuronal development |
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regulates the homeobox transcription factor NANOG fonctions |
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Med12-Med13-Cdk8-CycC subcomplex may be involved in |
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both positive and negative transcriptional regulation of all RNAPII promoters |
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essential for Nanog signaling and maintenance of ES cell pluripotency |
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Med12 and Nanog function together to regulate Nanog target gene promoters |
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has possible roles in development |
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controls the response to multiple cancer drugs through regulation of TGFBR signaling |
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involved in transcriptional regulation by conveying information from gene-specific regulatory elements to the RNA polymerase II transcription machinery |
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MED12 and KAT6B are chromatin-modifying enzymes implicated in Ohdo syndrome and the development of uterine leiomyomata and other tumors strongly suggests that both genes are functionally related |
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is an essential regulator of hematopoietic stem cell (HSC) homeostasis |
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alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis |
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MED12 plays a key role in the regulation of uterine fibroid cell line (HuLM) cell proliferation through the modulation of WNT/CTNNB1, cell cycle-associated, and fibrosis-associated protein expression |
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is an important molecular regulator of tumor dormancy in epithelial ovarian cancer (EOC) |
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