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FLASH GENE

Symbol

APBA3

contributors: mct/npt - updated : 08-09-2012

HGNC name	amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
HGNC id	580

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   decreases macrophage invasion constitutional     --low   abrogates MMP14-mediated ATP production and ATP-dependent cell motility

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   potential new therapeutic target to regulate macrophage-mediated inflammation

ANIMAL & CELL MODELS