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FLASH GENE
Symbol APBA3 contributors: mct/npt - updated : 08-09-2012
HGNC name amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
HGNC id 580
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • at the N terminus, several putative SH3 binding motifs three protein-protein interaction domains, and a nuclear export signal (NES), mutation of which induces nuclear accumulation of EGFP-APBA3 in the absence of leptomycin B
  • a phosphotyrosine-binding (PTB) domain essential for the binding of FURIN (this binding affects the TGN-specific localization of FURIN)
  • a PID/PTB and two C terminal PDZ elements
  • HOMOLOGY
    interspecies homolog to C.elegans k03d3.6
    Homologene
    FAMILY
  • X11 protein family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text attached to the plasma membrane by C terminal PDZ domains
    basic FUNCTION
  • modulating processing of the beta-APP and hence formation of beta-APP
  • stimulates MMP24 activity when expressed at low levels in an EWV-dependent fashion, but inhibits its activity at higher levels independent of the EWV motif
  • potentially functions in the nucleus by a mechanism distinct from conventional transactivators
  • adaptor scaffolding protein involved in formation of multiprotein complexes, and trafficking and metabolism of membrane proteins such as the beta-amyloid precursor protein
  • may be the adaptor proteins that regulate the trafficking of MMP24
  • regulates FURIN distribution mainly through interaction with the acidic peptide signal of Furin
  • regulates the HIF1AN-HIF1A pathway, which controls ATP production in macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component HIF1AN forms a complex with APBA3, and these two factors co-localize within the perinuclear region
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Alzheimer beta-amyloid precursor protein (APP)-(cytoplasmic domain)
  • BCR (breakpoint cluster region) protein binds to PDZ-domain vesicle coat protein APBA3
  • MMP14 activates HIF1A via APBA3 in many types of cell so as to stimulate glycolysis
  • interaction with MMP14 (APBA3-dependent mechanism represents the effect of MMP14 on ATP production in macrophages)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreases macrophage invasion
    constitutional     --low  
    abrogates MMP14-mediated ATP production and ATP-dependent cell motility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    potential new therapeutic target to regulate macrophage-mediated inflammation
    ANIMAL & CELL MODELS