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FLASH GENE

Symbol

KCNE2

contributors: mct/npt - updated : 26-04-2017

HGNC name	potassium voltage-gated channel, Isk-related family, member 2
HGNC id	6242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LQT6 , ATFB5

related resource

Gene Connection for the Heart - Long QT Syndrome database Long QT Syndrome Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy

Susceptibility

to atrial fibrillation and arythmia to antibiotic-induced cardiac arrhythmia

Variant & Polymorphism SNP	increasing the arrhythmia risk
	potassium currents inhibited by sulfamethoxazole at therapeutic levels

Candidate gene
Marker
Therapy target	semispecific, reversible pharmacological targeting of the KCNQ1-KCNE2 complex to treat thyroid disease (Roepke 2009)

ANIMAL & CELL MODELS

Kcne2-deficient mice had hypothyroidism, dwarfism, alopecia, goiter and cardiac abnormalities including hypertrophy, fibrosis, and reduced fractional shortening (Roepke 2009)