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FLASH GENE
Symbol KCNE2 contributors: mct/npt - updated : 26-04-2017
HGNC name potassium voltage-gated channel, Isk-related family, member 2
HGNC id 6242
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveintestinelarge intestinecolon highly
Endocrinepancreas   highly
 thyroid   highly
Reproductivefemale systemovary  lowly
 male systemtestis  lowly
 male systemprostate  lowly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrinethyroid cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-linked glycosylation sites
  • a single transmembrane segment
  • consensus sequences for two protein kinase C-mediated phosphorylation sites
  • a C-terminus having only minimal influences on KCNQ1
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Kcne1
    Homologene
    FAMILY
  • potassium channel KCNE family
  • Isk-related subfamily member (IRK)
  • CATEGORY motor/contractile , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume
  • having a role as a membrane-spanning subunit within voltage-gated potassium channel complexes (Abbott 2008)
  • can associate with the KCNQ1-KCNE1 complex to suppress the current amplitude without altering the slow gating kinetics (Jiang 2009)
  • in cardiac myocytes, control cardiac slow delayed rectifier (IKs) channel current amplitude in the cell membrane (Jiang 2009)
  • required for normal thyroid hormone biosynthesis (Roepke 2009)
  • potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone–stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis (Roepke 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramers KCNH2/KCNE2, KCNQ1/KCNE2
  • heteromeric channels KCNQ1/KCNE2—originally recognized for their functional roles in repolarizing cardiac myocytes—form a constitutively active K+ channel in thyrocytes (Roepke 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with KCNH2 (HERG) to generate a rapid delayed-rectifier channel (differing from the channel exclusively made of KCNH2), central to the control of the heart rate and rhythm
  • interacting with KCNQ1 resulting in a drastic change of current amplitude and gating properties
  • influences blood-cerebrospinal fluid anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium
  • KCNE1 and KCNE2 cleavages are regulated by BACE1 and PSEN1/gamma-secretase activities under physiological conditions
  • conductance and dynamics of KCNQ1 could be modulated by different single transmembrane helical auxiliary proteins (such as KCNE1, KCNE2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LQT6 , ATFB5
    related resource Gene Connection for the Heart - Long QT Syndrome database
    Long QT Syndrome Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy
    Susceptibility
  • to atrial fibrillation and arythmia
  • to antibiotic-induced cardiac arrhythmia
  • Variant & Polymorphism SNP
  • increasing the arrhythmia risk
  • potassium currents inhibited by sulfamethoxazole at therapeutic levels
  • Candidate gene
    Marker
    Therapy target semispecific, reversible pharmacological targeting of the KCNQ1-KCNE2 complex to treat thyroid disease (Roepke 2009)
    ANIMAL & CELL MODELS
    Kcne2-deficient mice had hypothyroidism, dwarfism, alopecia, goiter and cardiac abnormalities including hypertrophy, fibrosis, and reduced fractional shortening (Roepke 2009)