| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| LOH
|
|
|
|
in breast cancer, neuroblastoma and others tumors |
| tumoral
|
| amplification
|
|
|
colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling ( |
| tumoral
|
| LOH
|
|
|
|
in hepatocellular, colorectal and ovarian carcinoma |
| tumoral
| somatic mutation
|
|
|
|
|
in hepatocellular carcinoma and hepatoblastoma |
| tumoral
|
|
|
| loss of function
|
|
in colon cancer |
| tumoral
|
|
|
|
|
|
frameshift mutations are common in gastric carcinoma with high microsatellite instability (MSI) and may contribute to development of gastric cancers with high MSI by deregulating the Wnt signaling in the affected cancer cells ( |
| constitutional
|
|
|
| loss of function
|
|
leads to supraphysiological WNT levels that disrupt hematopoietic stem cells differentiation and thymocyte development |
| tumoral
|
|
| --low
|
|
|
independently associated with more aggressive prostate cancer (PCa), biochemical recurrence, and metastasis-free survival after Radical prostatectomy (RP) |
| constitutional
| germinal mutation
|
|
|
|
|
could be a potential cause in human calvarial malformations, especially for the sagittal synostosis |
