Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | AXIN2 | contributors: mct/shn - updated : 13-08-2012 |
HGNC name | axin 2 |
HGNC id | 904 |
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DNA |
TYPE | functioning gene |
STRUCTURE | 33.06 kb 11 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site transcription factor | |
text structure |
MAPPING | cloned | Y | linked | N | status | confirmed |
Map | cen - D17S1825 - D17S1792 - AXIN2 - D17S1882 - D17S1874 - qter |
Physical map
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RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
tissue |
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cell lineage | immature oligodendrocyte progenitor cells in white matter lesions of human newborns with neonatal hypoxic-ischemic and gliotic brain damage (![]() | |
cell lines
fluid/secretion
| blood | |
at STAGE |
physiological period | embryo |
Text | embryonic tissue |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | PhosphoP |
mono polymer | homomer , heteromer , oligo |
HOMOLOGY |
interspecies | ortholog to axin2, Danio rerio |
ortholog to Axin2, Rattus norvegicus | |
ortholog to Axin2, Mus musculus |
intraspecies | homolog to AXIN1 |
Homologene |
FAMILY |
CATEGORY | chaperone/stress , regulatory |
SUBCELLULAR LOCALIZATION
| intracellular |
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome | |
intracellular,nucleus | |
text | located to centrosome by binding to CEP250 (Hadjihannas 2010) |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
negative regulator of the signaling Wnt pathway through interaction with GSK3B and beta catenin |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | ![]() |
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cell & other |
REGULATION |
repressed by | RUNX2, HDAC3, that repress AXIN2 transcription in osteoblasts ![]() |
Other | phosphorylated by GSK3B and dephosphorylated by PP2A |
ASSOCIATED DISORDERS |
corresponding disease(s) | FTACC |
Other morbid association(s) |
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Susceptibility |
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Variant & Polymorphism SNP | |
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Candidate gene | strong candidate in multiple tumor types | ||||||||||||||
Marker
Therapy target
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ANIMAL & CELL MODELS |
disruption of Axin2 in mice induces skeletal defects, a phenotype resembling craniosynostosis in humans |