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FLASH GENE

Symbol

PLD2

contributors: mct/shn/pgu - updated : 07-12-2015

HGNC name	phospholipase D2
HGNC id	9068

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment

Susceptibility

Variant & Polymorphism SNP	rs2286672 correlates with risk for hypertension

Candidate gene	active PLD2 enhances processes favorable to lymphoma cell metastasis whereas expression of inactive PLD2 inhibits metastasis
Marker
Therapy target

ANIMAL & CELL MODELS